Also known asDr. Ernest Armstrong McCulloch
Ernest Armstrong McCulloch was a cellular biologist, co-discoverer of the existence of stem cells. Born in Toronto, Ontario April 27, 1926; died there January 20, 2011. McCulloch was educated at Upper Canada College and the University of Toronto; 1948 received his MD from UofT; began research at the Lister Institute in London, England; 1957 joined the newly formed Ontario Cancer Institute to focus on normal blood-formation and leukemia; with James Till, created the first quantitative, clonal method to identify stem cells and used this technique for pioneering studies on stem cells; early 1960s experimented with injecting bone marrow cells into irradiated mice. Visible nodules were observed in the spleens of the mice, in proportion to the number of bone marrow cells injected. They called the nodules 'spleen colonies', and speculated that each nodule arose from a single marrow cell: perhaps a stem cell; 1963 published their results in Nature; 1963 collaborating with molecular biologist Lou Siminovitch, they showed that these cells were capable of self-renewal; did later research on cellular and molecular mechanisms affecting the growth of malignant blast stem cells obtained from the blood of patients with Acute Myeloblastic Leukemia.
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Dr. ERNEST ARMSTRONG McCULLOCH O.C., O. Ont., F.R.S, D.S., (Hon.), M.D., F.R.S. (C), F.R.C.P. (C) Passed away peacefully on January 20, 2011 in his 85th year, in the company of his beloved wife Ona. He will be remembered with love by his sister Tot Johnston, by his children James, Michael, Robert, Cecilia and Paul and their spouses Kim, Nancy, Douglas and Kim. His memory will be cherished and protected by his grandchildren, Alex and Sam McCulloch, Kate and Steve McCulloch and Beth and Hugh MacIntyre. His great-grandson Charles Smith contributed to the joy of Dr. McCulloch's last Christmas celebration. All who wish to pay their respects may visit at the Turner & Porter Yorke Chapel, 2357 Bloor St. W., Toronto, at Windermere east of the Jane subway between 2:00 and 4:00 p.m. on Saturday, January 22nd and Sunday, January 23, 2011. A service will be held in the chapel for family and close friends on Monday, January 24, 2011 at 11:00 a.m. In lieu of flowers, donations may be made to the Ontario Cancer Institute.